| Museum | Location | County |
|---|
| Agricultural Heritage Center | Blackville | Barnwell |
| Aiken Center for the Arts | Aiken | Aiken |
| Aiken County Historical Museum | Aiken | Aiken |
| Aiken-Rhett House | Charleston | Charleston |
| Aiken Thoroughbred Racing Hall of Fame and Museum | Aiken | Aiken |
| American Legion Post 3 Cecil B. Buchanan War Museum | Greenville | Greenville |
| American Military Museum | Charleston | Charleston |
| Anderson City Fire Department Museum | Anderson | Anderson |
| Anderson County Museum | Anderson | Anderson |
| Andrew Jackson State Park | Lancaster | Lancaster |
| Antiquers Haven Museum and Shop | Liberty | Pickens |
| Arts and Heritage Center of North Augusta | North Augusta | Aiken |
| Ashtabula Historic House | Pendleton | Anderson |
| Avery Research Center | Charleston | Charleston |
| Barnwell County Museum | Barnwell | Barnwell |
| Bart Garrison Agricultural Museum of South Carolina | Pendleton | Anderson |
| Beaufort Arsenal | Beaufort | Beaufort |
| Beaufort History Museum | Beaufort | Beaufort |
| Bedon-Lucas House | Walterboro | Colleton |
| Beech Island Historical Society Visitors Center & Barn | Beech Island | Aiken |
| Berkeley County Museum and Heritage Center | Moncks Corner | Berkeley |
| Best Friend of Charleston Museum | Charleston | Charleston |
| Black Creek Arts Council Gallery | Hartsville | Darlington |
| BMW Zentrum | Spartanburg | Spartanburg |
| Bob Campbell Geology Museum | Clemson | Pickens |
| Bob Jones University Museum and Gallery | Greenville | Greenville |
| Bonham House | Saluda | Saluda |
| Boone Hall Plantation and Gardens | Mount Pleasant | Charleston |
| Brookgreen Gardens | Murrells Inlet | Georgetown |
| Browntown Museum | Hemingway | Williamsburg |
| Burt-Stark Mansion | Abbeville | Abbeville |
| Button Museum | Bishopville | Lee |
| Calhoun Mansion | Charleston | Charleston |
| Camden Archives & Museum | Camden | Kershaw |
| Catawba Cultural Center | Rock Hill | York |
| Cayce Historical Museum | Cayce | Lexington |
| Central History Museum | Central | Pickens |
| Charles Pinckney National Historic Site | Mount Pleasant | Charleston |
| Charles Towne Landing State Historic Site | Charleston | Charleston |
| Charleston Museum | Charleston | Charleston |
| Cheraw Lyceum | Cheraw | Chesterfield |
| Cherokee County History and Arts Museum | Gaffney | Cherokee |
| Cherokee County Veterans Museum | Gaffney | Cherokee |
| Chester County Historical Society Museum | Chester | Chester |
| Chester County Transportation Museum | Chester | Chester |
| Children's Museum of South Carolina | Myrtle Beach | Horry |
| Children's Museum of the Lowcountry | Charleston | Charleston |
| Children's Museum of the Upstate | Greenville | Greenville |
| The Citadel Archives & Museum | Charleston | Charleston |
| Clemson Area African American Museum | Clemson | Pickens |
| Clemson University Galleries | Clemson | Pickens |
| Clinton Museum | Clinton | Laurens |
| Coastal Discovery Museum | Hilton Head Island | Beaufort |
| Coker Farms National Historic Landmark | Hartsville | Darlington |
| Colleton Museum | Walterboro | Colleton |
| Collins Ole Towne | Central | Pickens |
| Columbia Fire Department Museum | Columbia | Richland |
| Columbia Museum of Art | Columbia | Richland |
| Communication Museum | Charleston | Charleston |
| Comporium Telephone Museum | Rock Hill | York |
| Confederate Museum | Charleston | Charleston |
| Congaree National Park | Hopkins | Richland |
| Cowpens Depot | Cowpens | Spartanburg |
| Cowpens National Battlefield | Chesnee | Cherokee |
| Darlington Raceway Stock Car Museum | Darlington | Darlington |
| Dillon County Museum | Latta | Dillon |
| Drayton Hall | Charleston | Charleston |
| Edisto Island Museum | Edisto Island | Charleston |
| Edmondston-Alston House | Charleston | Charleston |
| EdVenture | Columbia | Richland |
| Fairfield County Museum | Winnsboro | Fairfield |
| Florence County Museum | Florence | Florence |
| Florence Railroad Museum | Florence | Florence |
| Fort Hill | Clemson | Pickens |
| Fort Moultrie National Monument | Sullivan's Island | Charleston |
| Fort Sumter National Monument | Charleston | Charleston |
| Francis Marion University Galleries | Florence | Florence |
| Franklin G. Burroughs-Simeon B. Chapin Art Museum | Myrtle Beach | Horry |
| Georgetown County Museum | Georgetown | Georgetown |
| Gibbes Museum of Art | Charleston | Charleston |
| Greenville County Museum of Art | Greenville | Greenville |
| Greenville Cultural Exchange Center | Greenville | Greenville |
| Greenwood Railroad Historical Center | Greenwood | Greenwood |
| Greer Heritage Museum | Greer | Spartanburg |
| Hagood-Mauldin House/Irma Morris Museum of Fine Arts | Pickens | Pickens |
| Hagood Mill Historic Site and Folklife Center | Pickens | Pickens |
| Halsey Institute of Contemporary Art | Charleston | Charleston |
| Hampton Colored School | Hampton | Hampton |
| Hampton County Museum | Hampton | Hampton |
| Hampton Museum and Visitors' Center | Hampton | Hampton |
| Hampton Plantation | McClellanville | Charleston |
| Hampton-Preston House | Columbia | Richland |
| Hanover House | Clemson | Pickens |
| Hartsville Museum | Hartsville | Darlington |
| Heyward House | Bluffton | Beaufort |
| Heyward-Washington House | Charleston | Charleston |
| Historic Brattonsville | McConnells | York |
| Historic Camden Revolutionary War Site | Camden | Kershaw |
| Hobcaw Barony | Georgetown | Georgetown |
| Hollywood Wax Museum | Myrtle Beach | Horry |
| Hopsewee Plantation | Georgetown | Georgetown |
| Horry County Museum | Conway | Horry |
| The Hunley | Charleston | Charleston |
| Hunting Island Light | Hunting Island | Beaufort |
| Huntington Beach State Park | Murrells Inlet | Georgetown |
| Jacob Kelley House | Hartsville | Darlington |
| John Mark Verdier House | Beaufort | Beaufort |
| Joseph Manigault House | Charleston | Charleston |
| James W. Dillon House | Dillon | Dillon |
| Kaminski House Museum | Georgetown | Georgetown |
| Karpeles Manuscript Library Museum | Charleston | Charleston |
| Kazoo Museum | Beaufort | Beaufort |
| Keowee-Toxaway Museum | Six Mile | Pickens |
| Kilgore-Lewis House | Greenville | Greenville |
| Kings Mountain National Military Park | Blacksburg | Cherokee |
| Kings Mountain State Park | Blacksburg | Cherokee |
| L.W. Paul Living History Farm | Conway | Horry |
| Lake Greenwood State Recreation Area | Ninety Six | Greenwood |
| Lando Manetta Mills History Center | Lando | Chester |
| Landsford Canal State Park | Catawba | Chester |
| Lexington County Museum | Lexington | Lexington |
| Louis G. Gregory Bahá'í Museum | Charleston | Charleston |
| Lowcountry Visitor's Center and Museum | Yemassee | Colleton |
| Lunney House Museum | Seneca | Oconee |
| Mac's Pride Museum | McBee | Chesterfield |
| Macaulay Museum of Dental History | Charleston | Charleston |
| Mace Brown Museum of Natural History | Charleston | Charleston |
| Magnolia Plantation and Gardens | Charleston | Charleston |
| Main Street Children's Museum | Rock Hill | York |
| Mann-Simons Site | Columbia | Richland |
| Marion County Museum | Marion | Marion |
| Marlboro County Historical Museum | Bennettsville | Marlboro |
| McBee Depot Library and Railroad Museum | McBee | Chesterfield |
| McLeod Plantation Historic Site | Charleston | Charleston |
| McKissick Museum | Columbia | Richland |
| Middleton Place | Summerville | Dorchester |
| Millford Plantation | Pinewood | Sumter |
| Miniature World of Trains | Greenville | Greenville |
| Monsanto Gallery | Greenwood | Greenwood |
| Mt. Croghan Museum | Mount Croghan | Chesterfield |
| Museum & Gallery at Heritage Green | Greenville | Greenville |
| Museum and Library of Confederate History | Greenville | Greenville |
| The Museum in Greenwood | Greenwood | Greenwood |
| Museum of Education | Columbia | Richland |
| Museum of the Cherokee in South Carolina | Walhalla | Oconee |
| Museum of York County | Rock Hill | York |
| Musgrove Mill State Historic Site | Cross Anchor | Spartanburg |
| Nathaniel Russell House | Charleston | Charleston |
| National Steeplechase Museum | Camden | Kershaw |
| Ninety Six National Historic Site | Ninety Six | Greenwood |
| North Charleston and American LaFrance Fire Museum and Educational Center | North Charleston | Charleston |
| North Myrtle Beach Historical Museum | North Myrtle Beach | Horry |
| Nostalgia City and Museum | Myrtle Beach | Horry |
| Oconee Heritage Center | Walhalla | Oconee |
| Oconee Station State Historic Site | Walhalla | Oconee |
| Oconee Veterans Museum | Walhalla | Oconee |
| Old Exchange Building | Charleston | Charleston |
| Old Santee Canal Park | Moncks Corner | Berkeley |
| Old Slave Mart | Charleston | Charleston |
| Parris Island Museum | Parris Island | Beaufort |
| Patriot's Point Naval & Maritime Museum | Mount Pleasant | Charleston |
| Pauline Pratt Webel Museum | Ridgeland | Jasper |
| Pickens County Museum of Art & History | Pickens | Pickens |
| Postal History Museum | Charleston | Charleston |
| Powder Magazine | Charleston | Charleston |
| Price House | Spartanburg | Spartanburg |
| Ravenel Caw Caw Interpretive Center | Ravenel | Charleston |
| Rebecca Randall Bryan Gallery | Conway | Horry |
| Redcliffe Plantation State Historic Site | Beech Island | Aiken |
| REVIVA Museum | Iva | Anderson |
| Rice Museum | Georgetown | Georgetown |
| Ripley's Believe It or Not! | Myrtle Beach | Horry |
| Robert Mills House | Columbia | Richland |
| Ronald McNair Life History Center | Lake City | Florence |
| Roper Mountain Science Center | Greenville | Greenville |
| Rose Hill Plantation State Historic Site | Union | Union |
| Ruth Drake Museum | Belton | Anderson |
| Saluda County Museum | Saluda | Saluda |
| The Sandbox | Hilton Head Island | Beaufort |
| Seay House | Spartanburg | Spartanburg |
| Seibels House and Garden | Columbia | Richland |
| Shoeless Joe Jackson Museum and Baseball Library | Greenville | Greenville |
| Slave Relic Historical Museum | Walterboro | Colleton |
| Southern African American Heritage Center | Cheraw | Chesterfield |
| South Carolina Botanical Garden | Clemson | Pickens |
| South Carolina Civil War Museum | Myrtle Beach | Horry |
| South Carolina Confederate Relic Room and Military Museum | Columbia | Richland |
| South Carolina Cotton Museum | Bishopville | Lee |
| South Carolina Governor's Mansion | Columbia | Richland |
| South Carolina Law Enforcement Officers Hall of Fame | Columbia | Richland |
| South Carolina Maritime Museum | Georgetown | Georgetown |
| South Carolina Military Museum | Columbia | Richland |
| South Carolina Railroad Museum | Winnsboro | Fairfield |
| South Carolina State Museum | Columbia | Richland |
| South Carolina Tennis Hall of Fame | Belton | Anderson |
| South Carolina Tobacco Museum | Mullins | Marion |
| Spartanburg Art Museum | Spartanburg | Spartanburg |
| Spartanburg Regional History Museum | Spartanburg | Spartanburg |
| Spartanburg Science Center | Spartanburg | Spartanburg |
| Summerville-Dorchester Museum | Summerville | Dorchester |
| Sumter County Gallery of Art | Sumter | Sumter |
| Sumter County Museum | Sumter | Sumter |
| Union County Museum | Union | Union |
| Upcountry History Museum | Greenville | Greenville |
| U.S. Army Adjutant General's Corps Museum | Columbia | Richland |
| U.S. Army Basic Combat Training Museum | Columbia | Richland |
| U.S. Army Chaplain Museum | Columbia | Richland |
| U.S. Army Finance Corps Museum | Columbia | Richland |
| Village Museum | McClellanville | Charleston |
| Wagener Museum | Wagener | Aiken |
| Walnut Grove Plantation | Spartanburg | Spartanburg |
| War Between the States Museum | Florence | Florence |
| Warren Lasch Conservation Center | North Charleston | Charleston |
| White Home | Rock Hill | York |
| Williamsburgh Historical Museum | Kingstree | Williamsburg |
| Williston Museum | Williston | Barnwell |
| Winchester Museum | Edgefield | Edgefield |
| Winthrop University Galleries | Rock Hill | York |
| Woodburn Historic House | Pendleton | Anderson |
| Woodrow Wilson Family Home | Columbia | Richland |
| World of Energy | Seneca | Oconee |
| York W. Bailey Museum | St. Helena Island | Beaufort |
